Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep177 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

ER stress and toxic soluble misfolded proteins are present in diabetes and diabetic ketoacidosis in a sex dependent-manner

Furtado Janara , Bearss Nicole R. , Mccarthy Cameron G , Nazzal Munier , Hoffman William B. , Wenceslau Camilla F.

IntroductionDiabetes, a metabolic disease, is responsible for 1.6 million deaths each year. Type 2 diabetes (T2D) is the most common type (90%) that usually occurs in adults. Type 1 diabetes (T1D) an autoimmune disorder, affects more children and adolescents. Diabetic Ketoacidosis (DKA) is the most common acute cause of morbidity and mortality in youth with T1D. Soluble protein oligomers (SPOs), are a class of misfolded toxic proteins released during end...